On September 29, 1998, two months after the events of the first Resident Evil, most citizens of the Midwestern American mountain community Raccoon City have been transformed into zombies by the T-Virus, a biological weapon secretly developed by the pharmaceutical company Umbrella.
At a gas station outside of town, Leon S. Kennedy, a rookie police officer meets Claire Redfield, a college student looking for her brother Chris. The gas station is overrun with zombies and the two narrowly escape in a police car.
After being separated in Raccoon City, Leon and Claire agree to meet up at the Raccoon Police Department, which is infested by zombies and other monsters including the T-00, the latest model of Umbrella’s Tyrant line of bio-weapons, dispatched to hunt down and kill any survivors. The creatures and various obstacles prevent Leon and Claire from actually reuniting as they are forced to stay on the move to survive and find a way to escape Raccoon City.