even months after the Green Poison outbreak, several Strategic Homeland Division (SHD) agents are defending a civilian settlement from a bandit attack when the SHD Network, the system controlling their advanced technology and communications, suddenly shuts down and they receive a Division distress call from Washington D.C. The playerﾒs Agent makes their way to the city where the Division and the remains of the local Joint Task Force have set up their base of operations in the White House. After defeating an attack on the White House shortly after arriving in the city, the Agent is briefed on the general situation by Manny Ortega, the Division controller for D.C. The Agent learns that much of the countryﾒs leadership is either dead or missing and that much of the city is under the control of three main enemy factions: the Hyenas, a loosely organized group of several gangs, criminals, and anarchists who seek to take advantage of the chaos, the Outcasts, a fanatical group made up of the survivors of the various quarantine zones around the city who seek to exact revenge on those they believe responsible for their imprisonment and eventual infection, and the True Sons, a highly organized and ruthless group of former Joint Task Force personnel, disgruntled members of the US Armed Forces, paramilitaries, and other traitors and mutineers, led by former JTF officer Colonel Antwon Ridgeway, who seek to gain control over the entire capital. Ortega instructs the Agent to work with fellow Agent Alani Kelso to help assist civilian settlements, fight the various enemy groups, and restore the SHD network.