Three years after the events of the first game, Sebastian Castellanos (Marqus Bobesich) has left the Krimson City Police Department, haunted by his experiences at the Beacon Mental Hospital. His only child, Lily (Kiara Gamboa), supposedly perishes in their house fire, and his wife Myra (Elizabeth Saydah), unwilling to accept her daughter’s death, abandons him. This results in Sebastian descending into alcoholism. Drowning his sorrows in a bar, Sebastian is approached by former partner and Mobius agent Juli Kidman (Meg Saricks), who reveals that Lily is still alive. Sebastian is brought to a secret Mobius facility against his will, where he meets the head of the facility named the Administrator (Richard Neil). The Administrator explains that Lily is being used as the Core for a new STEM system to simulate an idyllic American town called Union. However, a week before the events of the game, Mobius lost contact with Lily and their agents inside Union, and they have lost control over the simulation. Sebastian reluctantly agrees to help and is plugged into STEM.